New PSP for Lorlatinib in 2nd line ALK translocated - Amivantamab + Lazertinib in first line mEGFR - Amivantamab + CT in second line EGFR post Osimertinib -

Update 5 October 2025

Pembrolizumab

Melanoma / Neoadjuvant

Québec / Canada

positive

Clinical Trials

Health Canada

INESSS (QC)

pCODR (CA)

pCPA

RAMQ / LM

The use of Pembrolizumab in neoadjuvant was not evaluated yet by authorities. But there was a wide uptake of this strategy, mainly due to the pCR and EFS data that we saw from the S1801.

In this trial, patients received neoadjuvant treatment with 3 doses of pembrolizumab q3w, followed by surgery, and then 15 adjuvant doses of pembrolizumab q3w.

Some authors are more skeptical of the design and analysis of this phase II study and recommend a phase III trial to approve the results before changing practice.

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Pembrolizumab

Melanoma / Neoadjuvant

Québec / Canada

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