New PSP for Lorlatinib in 2nd line ALK translocated - Amivantamab + Lazertinib in first line mEGFR - Amivantamab + CT in second line EGFR post Osimertinib -

Update 5 October 2025

Pembrolizumab + CT peri-op

Lung – NSCLC / Neoadjuvant

Québec / Canada

8 mos.

positive 3 June 2024

Clinical Trials

2 mos.

positive 11 February 2025

Health Canada

negative 30 April 2025

INESSS (QC)

positive 4 April 2025

pCODR (CA)

pCPA

RAMQ / LM

Comparison with other countries

United States

United States

5 mos.

positive 16 October 2023

FDA approval

Europe

Europe

10 mos.

positive 28 March 2024

EMA approval

Canada

Canada

positive 11 February 2025

Health Canada

With the OS benefit of Checkmate 816 and the lack of comparative studies, the adjuvant portion is gonna be a challenging issue. An indirect meta-analysis suggested that adjuvant post neoadjuvant “may not improve survival outcomes for patients with resectable NSCLC and may be associated with increased adverse events” adding to the high financial toxicity and the burden of months of therapy on the healthcare system.

Following INESSS’s negative recommendation, PSP closed in Quebec.

Two publications worth a read :

Adjuvant IO should not be used for patients who obtain pCR vs Adjuvant IO should be used for patients who obtain pCR

And finally a nice summary for NA, A and perioperative strategies in resectable NSCLC

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