New PSP for Lorlatinib in 2nd line ALK translocated - Amivantamab + Lazertinib in first line mEGFR - Amivantamab + CT in second line EGFR post Osimertinib -

Update 5 October 2025

CT: Platinum-based doublet

Lung – NSCLC / Metastatic

Québec / Canada

Clinical Trials

ECOG trial / nejm 2002

Health Canada

INESSS (QC)

pCODR (CA)

pCPA

RAMQ / LM

Comparison with other countries

United States

United States

FDA approval

Europe

Europe

EMA approval

Canada

Canada

Health Canada

CT alone is indicated in IO ineligible patients, with Carboplatin Paclitaxel or Carboplatin Gemcitabine being the most used.

Four combinations were randomly compared to each other a while now in the ECOG trial: cisplatin and paclitaxel / cisplatin and gemcitabine / cisplatin and docetaxel / carboplatin and paclitaxel.

“No significant difference in survival was observed among four commonly used regimens, although the regimen of car- boplatin and paclitaxel had a lower rate of toxic effects than the other regimens. On the basis of these results, ECOG has chosen carboplatin and paclitaxel as its reference regimen for future studies.”

The dosage in the trial of Carboplatin plus paclitaxel is : paclitaxel, 225 mg/m2 over 3-hr period on day 1 carboplatin, AUC 6.0 mg/ml/min on day 1 q 3-wk cycle x 4 cycles.

It is kind of impossible to replicate it in real life. The most common dosage is paclitaxel 175 mg/m2 over 3-hr period on day 1 carboplatin, AUC 4-5 on day 1 of a q 3-wk cycle x 4 cycles.

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