New PSP for Lorlatinib in 2nd line ALK translocated - Amivantamab + Lazertinib in first line mEGFR - Amivantamab + CT in second line EGFR post Osimertinib -

Update 5 October 2025

Cisplatin + Etoposide (A)

Lung – SCLC / Limited Stage

Québec / Canada

Clinical Trials

Health Canada

INESSS (QC)

pCODR (CA)

pCPA

RAMQ / LM

Four cycles of systemic therapy are recommended for LS-SCLC.

Cisplatin 60-75 mg/m2 day 1 & Etoposide 100-120 mg/m2 days 1-3

Other feasible regimens were developped based on comparison in different groups (elderly poor risk, with CRT, in first line metastatic…), with an efficacy that is questionable in this setting in my opinion:

Cisplatin 25 mg/m2 days 1-3 and etoposide 100 mg/m2 days 1-3

Carboplatin AUC5–6 day 1 & etoposide 100 mg/m2 days 1-3

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Cisplatin + Etoposide (A)

Lung – SCLC / Limited Stage

Québec / Canada

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